Design a sub-study of the 'aspirin in reducing events in the elderly' (aspree) trial, aspree-amd is a 5-year follow-up double-blind, placebo-controlled, randomized trial of the effect of 100 mg daily aspirin on the course of amd in 5000 subjects aged 70 years or older, with normal cognitive function and without cardiovascular disease at baseline. A dutch randomized clinical trial on aspirin and low molecular weight heparins in patients with recurrent miscarriage showed the lowest incidence of preterm birth in the aspirin group of 16%. Aspirin and simvastatin combination for cardiovascular events prevention trial in diabetes (accept-d): design of a randomized study of the efficacy of low-dose aspirin in the prevention of cardiovascular events in subjects with diabetes mellitus treated with statins. Low-dose aspirin was generally safe for the fetus and newborn infant, with no evidence of an increased likelihood of bleeding our findings do not support routine prophylactic or therapeutic administration of antiplatelet therapy in pregnancy to all women at increased risk of pre-eclampsia or iugr.
Assessments of between-group differences in any end point in this study were confounded by a decreasing level of adherence with daily low-dose aspirin in the aspirin group (dropping to 76% in year 5) and increasing uptake of daily aspirin in the no aspirin group (reaching 10% in year 5. Women's health study (whs): a randomized trial of low-dose aspirin and vitamin e in the primary prevention of cardiovascular disease and cancer (whs) the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Thus, these randomized trial data tend to exclude any large beneficial effect of 5 years of low-dose aspirin treatment on arm, although a smaller, but potentially important, beneficial effect cannot be ruled out. A randomized trial of low-dose aspirin in the prevention of clinical type 2 diabetes in women aruna d pradhan, md 1,2,3,4 nancy r cook,scd 1,2,3 joann e manson, md 3 paul m ridker, md.
There was also no overall reduction in cancer risk in the women's health study—a randomized clinical trial that tested whether every-other-day use of low-dose aspirin could reduce cancer risk in nearly 40,000 women aged 45 and over. Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on the risk of ischemic stroke. The jpad trial (japanese primary prevention of atherosclerosis with aspirin for diabetes) was a randomized, open-label, standard care-controlled trial examining whether low-dose aspirin affected cardiovascular events in 2539 japanese patients with type 2 diabetes mellitus and without preexisting cardiovascular disease.
Aspree-neuro study protocol: a randomized controlled trial to determine the effect of low-dose aspirin on cerebral microbleeds, white matter hyperintensities, cognition, and stroke in the healthy elderly. We assessed whether long-term low-dose aspirin therapy reduces the incidence of clinical type 2 diabetes in the randomized treatment arms of the women's health study (whs) the whs tested the efficacy of low-dose aspirin in the primary prevention of cardiovascular disease and cancer over a 10-year period in a large group of initially healthy women. However, even at the low dose evaluated in this trial, the use of aspirin was associated with a significant increase in clinically important bleeding events and any potential benefit at higher doses, if found, must take into account this potential for excess risk.
The first randomized trial of aspirin for heart attack archie cochrane, my predecessor as director of the uk medical research council's epidemiology research unit in cardiff, was inclined to play down his own work and to encourage others. Objectives: to determine whether low-dose aspirin reduces the incidence of pre-eclampsia, reduces perinatal mortality and improves birth weights in pregnant women considered at high risk of developing pre-eclampsia. Randomized controlled trial using low-dose aspirin in the prevention of pre-eclampsia in women with abnormal uterine artery doppler at 23 weeks' gestation ultrasound obstet gynecol 200322:233-9.
A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women paul m ridker, md, nancy r cook, scd, cebo-controlled trial of low-dose aspirin in the pri. Using individual patient data, we analysed the modifying effects of bodyweight (10 kg bands) and height (10 cm bands) on the effects of low doses (≤100 mg) and higher doses (300-325 mg or ≥500 mg) of aspirin in randomised trials of aspirin in primary prevention of cardiovascular events. Objective: to evaluate the efficacy of low-dose aspirin in the primary prevention of myocardial infarction among patients with chronic stable angina design: a randomized, double-blind, trial. The aspree-neuro trial is to our knowledge the first randomized controlled trial to assess the impact of daily, low-dose aspirin on the number of cmbs (primary outcome measure.
This trial included 156 adults with cardiovascular disease, history of aspirin use, and acute peptic ulcer bleeding immediately after successful endoscopic treatment, they were randomly assigned to receive low-dose aspirin (80 mg/d) or placebo for 8 weeks. Low-dose aspirin is a common strategy for preventing cardiovascular disease and associated mortality a recent individual patient data meta-analysis of 8 trials of low- and high-dose aspirin, with long-term follow-up, found important reductions in cancer mortality. The scottish pregnancy intervention (spin) study was designed as a pragmatic, multicenter, randomized controlled trial to assess whether treatment with enoxaparin and low-dose aspirin, along with intensive pregnancy surveillance, in those with a history of 2 or more consecutive pregnancy losses at 24 or fewer weeks' gestation and with no. We assessed whether long-term low-dose aspirin therapy reduces the incidence of clinical type 2 diabetes in the randomized treatment arms of the women's health study (whs.
Conducted a meta-analysis using data from all randomized clinical trials evaluating low-dose (75-325 mg) daily aspirin we extracted data on non-cardiovascular disease mortality and cancer mortality. Clasp: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women clasp (collaborative low-dose aspirin study in pregnancy) collaborative group.